Key result
Crystal structures of human antiviral Fabs reveal novel features enabling potent and broad target neutralization.
Highlights novel structural features of human antiviral Fabs that enable potent and broad target neutralization.
May inform broad antiviral antibody design; leaves open clinical translation pending prospective validation.
A brief outline of antibody structure is followed by highlights from several recently determined crystal structures of human, antiviral Fabs. These Fabs all have novel structural features that allow them to potently and broadly neutralize their targets.
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Stanfield et al. (2014) studied this question. Recently determined crystal structures of human, antiviral Fabs reveal novel structural features that enable potent and broad neutralization of their targets.
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