Key result
Carbon ion radiotherapy provides good local control with mild toxicity in two unusual liposarcoma patients.
Why the study?
Is carbon ion radiotherapy effective and safe for unusual liposarcomas?
Case Report (n=2)
No
Is carbon ion radiotherapy effective and safe for unusual liposarcomas?
Carbon ion radiotherapy may be an effective and safe option for unusual liposarcomas, particularly when surgery is declined or in recurrent disease.
Answers are grounded in this paper and cite their sources.
Hypothesis-generating for carbon ion radiotherapy in rare liposarcomas; prospective trials needed before clinical adoption.
BACKGROUND: Liposarcomas are the most common soft-tissue sarcomas in adulthood. Orbital and spermatic cord liposarcomas are uncommon and there is no consensus on their management. The treatment of choice is wide excision, which may be destructive and lead to unacceptable morbidity. When surgery is declined by patients and in recurrent disease, management can be challenging. We report two cases of liposarcoma treated with carbon ion radiotherapy at the National Center for Oncological Hadrontherapy (Fondazione CNAO) in Italy. CASE REPORT: A woman with orbital liposarcoma and a man with spermatic cord liposarcoma were referred to our Center and accepted for carbon ion radiotherapy. The treatment was well tolerated and late toxicities were mild. Good local control was achieved in patients. CONCLUSION: In our experience, carbon ion radiotherapy is an effective and safe option, especially in cases of tumor at high risk for local relapse, in patients with multiple local recurrences, and in patients who refuse destructive surgery.
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Vitolo et al. (2019) conducted a case report in Orbital and spermatic cord liposarcomas (n=2). Carbon ion radiotherapy was evaluated on Local control and toxicity. Carbon ion radiotherapy was well tolerated with mild late toxicities and achieved good local control in two patients with unusual liposarcomas.
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