Key result
Cowden syndrome presents with breast cancer and bilateral exuberant benign masses in a 22-year-old woman.
Why the study?
Cowden syndrome is associated with an increased risk of developing breast cancer, but detailed imaging and clinical features in such cases are not well characterized.
Case Report (n=1)
Highlights the presentation of breast cancer in a young patient with Cowden syndrome, emphasizing the increased risk of breast cancer in this condition.
May prompt genetic testing for Cowden syndrome in young women with breast cancer plus bilateral benign masses; leaves open screening implications.
Cowden syndrome is an uncommon, autosomal dominant disease which is characterized by multiple hamartomas of the skin, mucous membrane, brain, breast, thyroid, and gastrointestinal tract. The diagnosis of Cowden syndrome implicates an increased risk of developing breast cancer. We report a case of a 22-year-old woman with Cowden syndrome that presented as breast cancer with concomitant bilateral exuberant benign masses in both breasts.
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Seo et al. (2014) conducted a case report in Cowden syndrome presenting as breast cancer (n=1). A 22-year-old woman with Cowden syndrome presented with breast cancer and concomitant bilateral exuberant benign masses in both breasts.
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