Key result
GII sapovirus strains from different clusters show distinct antigenicities on antigen ELISA.
Why the study?
The relationship between sapovirus genogroup II antigenicity and genetic clusters is not fully understood.
Population
Mammalian cells expressing virus-like particles of two GII sapovirus strains, Mc10 and C12
Comparison
Antigenicity of Mc10 strain versus C12 strain within GII genogroup clusters
Design
Preclinical study using antigen ELISA
Authors
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May limit assumptions of broad GII sapovirus cross-immunity; leaves open cluster-specific antigenicity studies before human vaccine translation.
Strains within the same GII sapovirus genogroup but different clusters exhibit distinct antigenicities.
T et al. (2009) studied Acute gastroenteritis (sapovirus infection). GII SaV strains Mc10 and C12 was evaluated on Antigenicity difference. Strains in the same GII sapovirus genogroup, but within different clusters, demonstrated distinct antigenicities based on antigen ELISA.
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