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December 1, 1997Journal of Medical Virology

Correlation of patient immune responses with genetically characterized small round-structured viruses involved in outbreaks of nonbacterial acute gastroenteritis in the United States, 1990 to 1995

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Key result

Patient immune responses to SRSV infection varied by genogroup, with genogroup I showing homologous responses despite up to 38.5% amino acid divergence, while genogroup II required <6.5%.

Population

Patients involved in 23 outbreaks of small round-structured virus gastroenteritis in the United States…

Design

Cross-sectional

Authors

JNJacqueline S. NoelThe Pelvic Floor InstituteTATamie AndoCenters for Disease Control and PreventionJLJosé Paulo Gagliardi LeiteFundação Oswaldo Cruz

Discussion

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Implication

May necessitate expanded antigens for serological detection across SRSV strains; extends understanding of genogroup-specific immunity.

Study Design

Type

Observational

Multicenter

Yes

Structured PICO

P
Population
Patients from 23 outbreaks of SRSV gastroenteritis in the United States between 1990 and 1995, evaluated for strain-specific immune responses.
E
Exposure
Molecular characterization (RT-PCR and nucleotide sequencing of a 277-base region of the capsid gene) and serologic assays (enzyme immunoassay using expressed capsid antigens of Norwalk virus, Toronto virus, Hawaii virus, and Lordsdale virus)
O
Outcome
Correlation of patient immune responses with genetically characterized SRSV strainssurrogate

While current molecular diagnostics can detect the full range of SRSVs, additional expressed antigens are required to detect immune responses across all antigenically diverse strains.

Limitations

  • Additional expressed antigens will be required to detect an immune response to SRSV infection caused by all the antigenically diverse strains.

Cite This Study

Noel et al. (1997) conducted an observational in Nonbacterial acute gastroenteritis. SRSV infection was evaluated on Serum IgG responses to expressed capsid antigens. Patient immune responses to SRSV infection varied by genogroup, with genogroup I showing homologous responses despite up to 38.5% amino acid divergence, while genogroup II required <6.5%.

synapsesocial.com/papers/6a1fc8052be0c1f4e3bb4177https://doi.org/10.1002/(sici)1096-9071(199712)53:4<372::aid-jmv10>3.0.co;2-h
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Capsid sequence diversity in small round structured viruses from recent UK outbreaks of gastroenteritis1997 · 56 citations
  2. 2Molecular characterisation of small round structured viruses associated with gastroenteritis in South Africa1995 · 27 citations
  3. 3Genomic diversity of small round structured viruses in the United Kingdom1994 · 65 citations
  4. 4Human enteric Caliciviridae: a new prevalent small round-structured virus group defined by RNA-dependent RNA polymerase and capsid diversity1994 · 110 citations
  5. 5Molecular characterization of Camberwell virus and sequence variation in ORF3 of small round-structured (Norwalk-like) viruses1996 · 51 citations