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May 1, 1997Journal of Medical Virology

Capsid sequence diversity in small round structured viruses from recent UK outbreaks of gastroenteritis

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Key result

A newly developed broadly reactive capsid PCR revealed that SRSV strains from recent UK gastroenteritis outbreaks belonged to genetic groups I and II, with Bri/93/UK-like strains appearing prevalent.

Population

Small round structured viruses from nine UK outbreaks of gastroenteritis occurring between 1992 and 1995…

Design

Preclinical

Authors

SGSteve M. GreenLoma Linda University Medical CenterPLPaul R. LambdenAhvaz Jundishapur University of Medical SciencesECE O CaulUniversity of Vermont

Discussion

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Implication

Enables SRSV strain surveillance in outbreaks; leaves open routine diagnostic adoption pending validation.

Structured PICO

P
Population
SRSV strains from 9 UK outbreaks of gastroenteritis between 1992 and 1995 were investigated using a newly developed capsid PCR.
E
Exposure
Broadly reactive capsid PCR using two sets of degenerate, inosine-containing primers (Capla/Caplb and Caplla/Capllb)
O
Outcome
Capsid sequence diversity and phylogenetic comparisonsurrogate

A newly developed broadly reactive capsid PCR enables genetic typing and epidemiological tracking of SRSV strains from gastroenteritis outbreaks.

Cite This Study

Green et al. (1997) studied Gastroenteritis. Capsid PCR using degenerate, inosine-containing primers was evaluated on Capsid sequence diversity and phylogenetic comparison. A newly developed broadly reactive capsid PCR revealed that SRSV strains from recent UK gastroenteritis outbreaks belonged to genetic groups I and II, with Bri/93/UK-like strains appearing prevalent.

synapsesocial.com/papers/6a1fc8052be0c1f4e3bb4178https://doi.org/10.1002/(sici)1096-9071(199705)52:1<14::aid-jmv3>3.0.co;2-u
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Polymerase chain reaction detection of small round‐structured viruses from two related hospital outbreaks of gastroenteritis using inosine‐containing primers1995 · 84 citations
  2. 2Rapid Evolution of RNA Viruses1987 · 592 citations
  3. 3Molecular characterisation of small round structured viruses associated with gastroenteritis in South Africa1995 · 27 citations
  4. 4Broadly reactive reverse transcriptase polymerase chain reaction for the diagnosis of SRSV‐associated gastroenteritis1995 · 209 citations
  5. 5Human enteric Caliciviridae: a new prevalent small round-structured virus group defined by RNA-dependent RNA polymerase and capsid diversity1994 · 110 citations