Key result
The Lordsdale Genotype II SRSV EIA identified SRSVs in 71% of positive gastroenteritis outbreaks, comparing favorably to electron microscopy (63%) and RT-PCR (84%).
Why the study?
Does an EIA based on recombinant capsid protein accurately detect SRSV in gastroenteritis outbreaks compared to EM and RT-PCR?
Population
Faecal specimens from 305 outbreaks of non-bacterial gastroenteritis sent to the Bristol Public Health…
Comparison
EIA based upon recombinant capsid protein from… vs Electron microscopy (EM) and RT-PCR assays
Design
Cross-sectional
Authors
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May simplify outbreak diagnostics over EM; leaves open prospective validation versus RT-PCR.
Observational (n=305)
No
Does an EIA based on recombinant capsid protein accurately detect SRSV in gastroenteritis outbreaks compared to EM and RT-PCR?
Absolute Event Rate: 71% vs 63%
The Lordsdale Genotype II SRSV EIA provides a simple, cost-effective assay with improved sensitivity over EM for detecting circulating SRSV strains in UK outbreaks.
Vipond et al. (2000) conducted an observational in Gastroenteritis outbreaks (n=305). Lordsdale Genotype II SRSV EIA vs. Electron microscopy (EM) and RT-PCR was evaluated on Detection of SRSVs in positive outbreaks. The Lordsdale Genotype II SRSV EIA identified SRSVs in 71% of positive gastroenteritis outbreaks, comparing favorably to electron microscopy (63%) and RT-PCR (84%).
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