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January 1, 2006Emerging infectious diseasesOpen Access

Genetic Diversity of Sapovirus in Children, Australia

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Key result

Sapovirus appears in ~7% of unexplained pediatric acute gastroenteritis cases, revealing all known human genogroups.

  • n=95

Why the study?

The genetic diversity of sapovirus in children with gastroenteritis of unknown etiology in Australia was not characterized.

Population

95 stool specimens from children with gastroenteritis of unknown etiology in Sydney, Australia

Design

Cross-sectional study using reverse transcription-polymerase chain reaction and sequence analysis

Authors

GHGrant S. HansmanGriffith UniversityNTNaokazu TakedaHyogo University of Health SciencesKKKazuhiko KatayamaHiroshima University

Discussion

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Implication

Sapovirus may contribute to unexplained pediatric gastroenteritis in Australia; extends genogroup diversity data but remains hypothesis-generating.

Study Design

Type

Cross-Sectional (n=95)

Multicenter

No

Structured PICO

P
Population
95 children aged 9 months to 7 years with acute gastroenteritis of unknown etiology treated at a single hospital in Sydney, Australia.
O
Outcome
Detection and genetic diversity of Sapovirus

Sapovirus is an important cause of acute gastroenteritis in children in Sydney, with a minimum prevalence of 4.1% and widespread genetic diversity.

Limitations

  • Small sample size from a single hospital
  • Specimens were not tested for Sapovirus if another etiologic agent was already identified
  • A more comprehensive study is needed to determine whether predominant Sapovirus strains are circulating
  • A more comprehensive study is needed to determine whether predominant SaV strains are circulating

Cite This Study

Hansman et al. (2006) conducted a cross-sectional in Acute gastroenteritis of unknown etiology (n=95). Sapovirus infection was evaluated on Detection of Sapovirus by RT-PCR. Sapovirus was detected in 7 of 95 (7.4%) stool specimens from children with acute gastroenteritis of unknown etiology in Sydney, Australia, revealing the presence of all known human genogroups.

synapsesocial.com/papers/6aae0b371491661de2a358d5https://doi.org/10.3201/eid1201.050846
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Outbreak of human calicivirus gastroenteritis in a day-care center in Sydney, Australia1991 · 39 citations
  2. 2Norovirus and Sapovirus Infections in Thailand2004 · 56 citations
  3. 3Genetic Diversity of Norovirus and Sapovirus in Hospitalized Infants with Sporadic Cases of Acute Gastroenteritis in Chiang Mai, Thailand2004 · 151 citations
  4. 4A 5‐year study of the prevalence and genetic diversity of human caliciviruses associated with sporadic cases of acute gastroenteritis in young children admitted to hospital in Melbourne, Australia (1998–2002)2005 · 114 citations
  5. 5Novel Recombinant Sapovirus2004 · 82 citations