Key result
Tadalafil 5 mg linked to ~39% higher vascular endothelial function and improved prostatic voiding symptoms.
Why the study?
The effects of tadalafil on vascular endothelial function and cardiovascular risk in patients with prostatic hyperplasia unresponsive to α1-blockers were investigated.
Does tadalafil improve vascular endothelial function and voiding symptoms in men with prostatic hyperplasia unresponsive to α1-blockers?
Does tadalafil improve vascular endothelial function and voiding symptoms in men with prostatic hyperplasia unresponsive to α1-blockers?
Absolute Event Rate: 1.89% vs 1.36%
p-value: p=< 0.05
Tadalafil improves both voiding symptoms and vascular endothelial function in men with prostatic hyperplasia who are unresponsive to α1-blockers.
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Tadalafil-associated endothelial changes in refractory BPH warrant no practice shift; leaves open cardiovascular risk modification for randomized confirmation.
Fukumoto et al. (2016) studied prostatic hyperplasia (n=20). Tadalafil vs. Baseline was evaluated on vascular endothelial function (reactive hyperemia index) (p=< 0.05). Tadalafil 5 mg significantly improved vascular endothelial function, increasing the reactive hyperemia index from 1.36 to 1.89 (P<0.05), and improved voiding symptoms in prostatic hyperplasia.
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