Key result
Higher long-term circulating platinum exposure is linked to paraesthesia in testicular cancer survivors.
Why the study?
Long-term and late effects related to healthy tissue damage after cisplatin-based chemotherapy for testicular cancer are not fully understood in relation to circulating platinum levels.
Is long-term exposure to circulating platinum associated with late effects of treatment in testicular cancer survivors?
Cohort (n=99)
Is long-term exposure to circulating platinum associated with late effects of treatment in testicular cancer survivors?
Absolute Event Rate: 30.9% vs 27%
p-value: p=0.021
Long-term circulating platinum exposure after cisplatin treatment is associated with late effects including paraesthesia, hypogonadism, hypercholesterolaemia, and hypertension in testicular cancer survivors.
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Persistent circulating platinum was associated with neuropathy and cardiometabolic late effects in survivors; leaves open whether kinetics-targeted interventions could reduce toxicity.
Boer et al. (2015) conducted a cohort in Testicular cancer (n=99). Long-term circulating platinum exposure vs. Lower platinum exposure was evaluated on Platinum AUC1-3 years in patients with vs without paraesthesia (p=0.021). Long-term circulating platinum exposure was significantly higher in testicular cancer survivors with paraesthesia compared to those without (30.9 vs 27.0 µg/l month; P=0.021).
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