Key result
Migraine attacks show reduced prodromal rCBF followed by a ~47% increase during the headache phase.
Why the study?
The onset of diabetes often precedes diagnosis by years and may be asymptomatic even in young patients, which is not sufficiently recognized.
Population
Young patients with diabetes
Authors
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May prompt earlier screening for youth with retinopathy; leaves open whether prediagnostic duration reliably informs type 1 diabetes onset.
Case Report (n=2)
No
Absolute Event Rate: 81% vs 55%
Highlights that asymptomatic diabetes may be present for years prior to diagnosis, even in young patients.
Skinhöj et al. (1969) conducted a case report in Migraine (n=2). Migraine attack (prodromal and headache phases) vs. Normal baseline state was evaluated on Regional cerebral blood flow (rCBF). During a migraine attack, regional cerebral blood flow was markedly reduced during the prodromal phase and significantly increased to 81 ml/100g/min during the headache phase compared to normal values.
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