Key result
Impaired glucose tolerance and T2D linked to ~28% lower cerebrovascular reactivity versus healthy volunteers.
Why the study?
Cerebrovascular autoregulation abnormalities and their association with cardiovascular autonomic nerve function in impaired glucose tolerance and type 2 diabetes were unclear.
Does impaired glucose tolerance or type 2 diabetes reduce internal carotid artery vascular reactivity compared to healthy volunteers?
Population
46 subjects including 12 with impaired glucose tolerance, 17 with type 2 diabetes, and 17 healthy volunteers
Comparison
Impaired glucose tolerance and type 2 diabetes vs healthy volunteers
Design
Cross-sectional study using quantitative magnetic resonance phase-contrast angiography
Authors
Loading...
May explain elevated cerebrovascular risk in dysglycemia; hypothesis-generating and requires longitudinal confirmation before practice change.
Cross-Sectional (n=46)
No
Does impaired glucose tolerance or type 2 diabetes reduce internal carotid artery vascular reactivity compared to healthy volunteers?
Absolute Event Rate: 41.5% vs 57%
p-value: p=0.02
Impaired glucose tolerance and type 2 diabetes are associated with significant cerebrovascular hemodynamic abnormalities and sympathovagal imbalance, which may explain the increased risk of cerebrovascular disease.
Selvarajah et al. (2016) conducted a cross-sectional in Impaired glucose tolerance and Type 2 Diabetes (n=46). Impaired glucose tolerance and Type 2 Diabetes vs. Healthy volunteers was evaluated on Internal carotid artery vascular reactivity (VRICA) in response to acetazolamide (p=0.02). Subjects with impaired glucose tolerance and type 2 diabetes had significantly lower cerebrovascular reactivity (40.2% and 41.5%, respectively) compared to healthy volunteers (57.0%, p=0.02).
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: