Key result
Common carotid artery elasticity measured by velocity vector imaging decreased significantly across healthy controls, uncomplicated diabetes, and complicated diabetes groups (p<0.05).
Why the study?
Carotid stiffening and endothelial dysfunction occur in type 2 diabetes mellitus, but the role of carotid elasticity in the development of diabetic vascular damage remains unclear.
Cross-Sectional (n=50)
p-value: p=<0.05
Carotid artery elasticity measured by velocity vector imaging may be a more sensitive indicator of early vascular damage in type 2 diabetes than flow-mediated dilation or intima-media thickness.
VVI carotid elasticity may detect graded vascular changes in diabetes; leaves open superiority to FMD or IMT.
BACKGROUND: Carotid stiffening is found to be present in patients with type 2 diabetes mellitus (T2DM) together with endothelial dysfunction and it remains unclear about the role of carotid elasticity in the development of diabetic vascular damage. The aim of the study was to investigate changes and significance of carotid artery elasticity in diabetic patients with or without microvascular complications using velocity vector imaging (VVI) analysis. METHODS: Fifty participants were enrolled and divided into health Control group, the uncomplicated DM (uDM) group and the complicated DM (cDM) group. All of them underwent carotid ultrasound examinations. VVI was used to evaluate the common carotid artery (CCA) elasticity and intima-media thickness (IMT) was also measured. Flow-mediated dilation (FMD) was performed to detect the vascular endothelial function. Then differences and correlations of variables between three groups were compared and analyzed. RESULTS: CCA elasticity measured by VVI decreased significantly between three groups (p < 0.05), while FMD decreased significantly only in cDM group (p < 0.01) and only IMT in cDM group was significantly thicker than that of Control group (p < 0.05). Representative VVI variables were independently, negatively related to the known duration and microalbuminuria (p < 0.05). All VVI variables were significantly correlated with FMD (0.5 ≤ |r | <0.8, p < 0.001), and just a small part of VVI variables were significantly correlated with IMT (0.3 ≤ |r | <0.5, p < 0.05). CONCLUSION: Compared with FMD, CCA elasticity measured by VVI showed more obvious changes in diabetic patients with different levels of vascular damage and may be considered as an alternative indicator in evaluating arterial status of T2DM.
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Jin et al. (2022) conducted a cross-sectional in Type 2 diabetes mellitus (n=50). Type 2 diabetes mellitus vs. Healthy controls was evaluated on Common carotid artery elasticity measured by velocity vector imaging (p=<0.05). Common carotid artery elasticity measured by velocity vector imaging decreased significantly across healthy controls, uncomplicated diabetes, and complicated diabetes groups (p<0.05).
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