Key result
VV-ECMO without systemic anticoagulation succeeds for 25 days without coagulation-related adverse events in one case.
Why the study?
The safety and feasibility of prolonged VV-ECMO without systemic anticoagulation in Goodpasture syndrome-related pulmonary haemorrhage is not well established.
Population
16-year-old male with Goodpasture syndrome and severe acute respiratory and renal failure
Comparison
VV-ECMO without systemic anticoagulation vs standard anticoagulation protocols
Design
Case report
Follow-up
26 ECMO days
Authors
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May support anticoagulation-free VV-ECMO in select bleeding cases; hypothesis-generating and requires prospective validation.
Case Report (n=1)
Prolonged VV-ECMO without systemic anticoagulation can be safely managed in patients with pulmonary hemorrhage without resulting in thrombotic events or circuit failure.
Herbert et al. (2014) conducted a case report in Goodpasture syndrome-related pulmonary haemorrhage (n=1). Prolonged venovenous extracorporeal membrane oxygenation (VV-ECMO) without systemic anticoagulation was evaluated on Coagulation-related adverse events, ECMO circuit failure, thrombotic events. Prolonged venovenous extracorporeal membrane oxygenation without systemic anticoagulation for 25 days was successfully performed in a 16-year-old male without coagulation-related adverse events.
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