Key result
LDH isoenzyme shifts in hypertrophic hearts associate with increased fibrous tissue over myocardial cell changes.
Why the study?
The distribution of lactate dehydrogenase isoenzymes in hypertrophic and ischaemic hypertrophic human hearts compared to normal hearts was not well characterized.
The shift in lactate dehydrogenase isoenzymes in hypertrophic hearts is associated with increased fibrous tissue rather than myocardial cell changes.
Answers are grounded in this paper and cite their sources.
LDH isoenzyme shifts in hypertrophy may reflect fibrosis more than myocytes; leaves open cellular sources and clinical relevance.
Lactate dehydrogenase isoenzymes have been measured in human hearts at autopsy. As compared with normal hearts, hypertrophic hearts and ischaemic hypertrophic hearts showed a shift in the isoenzyme distribution. This shift appeared to be more closely associated with an increase in the relative proportion of fibrous tissue than with changes in the myocardial cells.
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Revis et al. (1977) studied this question. Hypertrophic and ischaemic hypertrophic hearts showed a shift in lactate dehydrogenase isoenzymes that was more closely associated with increased fibrous tissue than with myocardial cell changes.
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