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Shows that thermoneutral housing lowers heart rate and blood pressure and blunts compensatory cardiac hypertrophy in mice, highlighting ambient temperature as a vital metabolic variable.
Thermoneutral housing conditions cause rapid and reversible changes in mouse heart rate and blood pressure. Despite dramatic reductions in heart rate and blood pressure, thermoneutrality reduced the compensatory hypertrophic response in a pressure overload heart failure model compared with room temperature housing, and ACE inhibitors were still efficacious to prevent pressure overload-induced cardiac remodeling. The effects of thermoneutrality on heart rate and blood pressure are abrogated in the context of diet-induced obesity.
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Chen et al. (2021) studied this question.
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