Key result
Preoperative dialysis before CABG is linked to ~25-fold higher 30-day mortality versus normal renal function.
Why the study?
The impact of decreasing preoperative renal function on short-term outcomes after primary coronary artery bypass grafting was evaluated due to its clinical significance.
Does decreasing preoperative renal function worsen short-term outcomes in patients undergoing primary CABG?
Cohort (n=4,050)
Does decreasing preoperative renal function worsen short-term outcomes in patients undergoing primary CABG?
Effect estimate: 25 times greater risk
Absolute Event Rate: 25% vs 0.96%
p-value: p=< .001
Primary CABG in patients with preoperative renal failure or on dialysis is associated with significantly higher short-term morbidity and mortality compared to those with normal renal function.
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Preoperative dialysis signals high 30-day mortality risk after CABG; this Level 3 association leaves open whether renal optimization improves outcomes.
Jayasekera et al. (2012) conducted a cohort in Coronary artery disease requiring primary CABG (n=4,050). Decreased preoperative renal function (creatinine >2 mg/dL or dialysis) vs. Normal preoperative renal function (creatinine <2 mg/dL) was evaluated on Short-term death (30 days) (25 times greater risk, p=< .001). Preoperative dialysis in patients undergoing primary CABG was associated with a 25% risk of 30-day mortality compared to 0.96% in patients with normal renal function (P < .001).
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