Key result
Preoperative mild renal dysfunction is linked to ~4-fold higher risk of adverse outcomes after CABG.
Why the study?
The impact of preoperative mild renal dysfunction on outcomes after isolated coronary artery bypass surgery was not clearly established.
Cohort (n=488)
No
Odds Ratio: 4.47 (95% CI 1.41–14.16)
p-value: p=0.010
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Mild preoperative renal dysfunction may elevate isolated CABG risk; extends dialysis-dependent evidence but remains hypothesis-generating.
Ramakrishna et al. (2008) conducted a cohort in Coronary Artery Disease requiring CABG (n=488). Preoperative mild renal dysfunction (serum creatinine 1.4-2.2 mg/dl) vs. Normal renal function (serum creatinine < 1.4 mg/dl) was evaluated on Poor postoperative outcome (morbidity and mortality) (Adj. OR 4.47, 95% CI 1.41-14.16, p=0.010). Preoperative mild renal dysfunction independently increased the risk of poor postoperative outcomes, including morbidity and mortality, in patients undergoing isolated CABG (Adj. OR 4.47).
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