Key result
Metoclopramide shows no difference versus dexamethasone for post-operative vomiting after abdominal surgeries.
Why the study?
Postoperative nausea and vomiting are common complaints after anesthesia and surgery, and the efficacy of metoclopramide versus dexamethasone for preventing postoperative vomiting after abdominal surgeries needed evaluation.
Does injection metoclopramide reduce postoperative vomiting compared to injection dexamethasone in patients undergoing abdominal surgery?
RCT (n=98)
Double-blind
Simple randomization
No
Does injection metoclopramide reduce postoperative vomiting compared to injection dexamethasone in patients undergoing abdominal surgery?
Metoclopramide and dexamethasone demonstrate comparable efficacy in preventing postoperative vomiting following abdominal surgery.
Postoperative nausea and vomiting are one of the most common complaints following anesthesia and surgery. This study was designed to evaluate the efficacy of dexamethasone and metoclopramide to prevent postoperative vomiting (POV) in patients undergoing abdominal surgeries. Objective: To compare the efficacy of injection metoclopramide with injection dexamethasone for POV after abdominal surgeries. Methods: This Randomized Double-Blind Controlled Trial was conducted in ward 3, Jinnah Postgraduate Medical Centre, Karachi for one year., upon a sample of 98 patients, aged 12 to 60 years and undergoing abdominal surgery (elective and emergency) divided into two groups (Group A: Injection Metoclopramide 10 mg, and Group B: Injection Dexamethasone 8mg), of 49 patients each. The incidence of POV were recorded during the first 24 h postoperatively. Results: The mean age of the sample stood at 31 (SD ± 03) years, with most of the sample comprising of males (72.45%). Vomiting was noted in both groups, with group a reporting vomiting among 07 individuals and group B reporting vomiting among 09 individuals. There was no statistical difference between the incidences of vomiting in both groups. Conclusion: After careful consideration, it may be concluded that both agents, namely metoclopramide and dexamethasone are efficacious at minimizing the incidence of POV and hence both may be used interchangeably or in conjunction among patients undergoing abdominal surgeries
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Rab et al. (2022) conducted an RCT in Post-operative vomiting (n=98). Metoclopramide vs. Dexamethasone 8 mg was evaluated on Incidence of post-operative vomiting during the first 24 hours (p=0.971). Metoclopramide 10 mg and dexamethasone 8 mg showed no significant difference in the incidence of post-operative vomiting after abdominal surgeries (14.29% vs 18.38%, p=0.971).
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