Key result
Filtering dilute red blood cells through small pores decreases relative flow resistance at high pressures.
Why the study?
A method to measure relative resistance of erythrocyte flow through small pores without buildup of deposits was needed to understand flow dynamics and membrane viscosity.
Population
Dilute red blood cell suspensions
Comparison
Flow through polycarbonate filters with and without cells
Design
Preclinical experimental study
Authors
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Hypothesis-generating for microvascular RBC flow; leaves open in vivo relevance and clinical translation.
The study demonstrates that erythrocyte flow resistance through small pores is highly dependent on pressure gradients and hematocrit, providing insights into precapillary sphincter control of microcirculation.
Blackshear et al. (1979) studied this question. Filtering dilute red blood cell suspensions through polycarbonate filters vs. Flow without cells was evaluated on Relative resistance of flow. Filtering dilute red blood cell suspensions through small pores (2.6-3 μm) showed relative resistance falling from a high value at low pressure drops to an asymptotic value at high pressure drops.
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