Key result
Metabolic syndrome links to worse cognitive dysfunction than single risk factors, driven by SBP and glucose.
Why the study?
The association between cognitive function and cardiovascular risk factors in middle-aged individuals, including those with metabolic syndrome, was investigated to develop a statistical model.
Observational
Cardiovascular risk factors, particularly metabolic syndrome, elevated glucose, and systolic blood pressure, are associated with worse cognitive function in middle-aged individuals.
May support cognitive screening in middle-aged metabolic syndrome; hypothesis-generating for glucose and SBP associations.
Objective. To find the association between cognitive function and cardiovascular risk factors and to develop statistic model. Results. Our study demonstrated that cognitive dysfunction is more profound in middle-aged patients with metabolic syndrome (MS) compared to the individuals with single risk factors without MS. Multiple regression analysis defined glucose (β = 0,0114) and systolic blood pressure (SBP) (β = -0,212) to be factors related with MMSE-test results. When glucose level was excluded from the model, the following factors were shown to be significant: SBP (β = -0,202), age (β = -0,093), operative memory (β = -0,169), total cholesterol level (β = -0,065), therapy by calcium antagonist (β = 0,082), obesity (β = 0,06), R = 92 %.
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Зуева et al. (2011) conducted an observational in Cardiovascular risk factors and metabolic syndrome. Metabolic syndrome vs. Single cardiovascular risk factors without metabolic syndrome was evaluated on Cognitive function (MMSE-test results). Metabolic syndrome was associated with more profound cognitive dysfunction compared to single risk factors, with systolic blood pressure (β=-0.212) and glucose (β=0.0114) related to MMSE scores.
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