Key result
Higher systolic BP and older age link to lower MMSE scores in isolated systolic hypertension.
Observational (n=3,111)
p-value: p=<0.001
In elderly patients with isolated systolic hypertension, cognitive status is inversely correlated with systolic blood pressure and age, and is significantly lower in those with cardiovascular complications.
Highlights potential cognitive risks in older adults with isolated systolic hypertension; hypothesis-generating for BP targets in preserving cognition.
Cognitive performance is predictive of functional status, morbidity and mortality in the elderly. In the SYST-EUR study, the Vascular Dementia Project run on 3,111 subjects 60 years old and over, with isolated systolic hypertension, has shown that the cognitive status as measured by the MMSE was inversely correlated with systolic blood pressure (p < 0.001) and age (p < 0.001) and positively correlated with the level of education (p < 0.001). It is significantly lower in patients with cardiovascular complications (p = 0.0001). Moderate alcohol consumption is linked to a higher MMSE score in women (p < 0.001) but not in men. In this study, the incidence of dementia is low and significantly related to the baseline value of the MMSE score and further analysis will show the influence of the treatment of systolic hypertension with calcium antagonists as first step on this incidence.
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Forette et al. (1998) conducted an observational in isolated systolic hypertension (n=3,111). Systolic blood pressure was evaluated on Cognitive status as measured by the MMSE (p=<0.001). Higher systolic blood pressure and older age were inversely correlated with cognitive status (MMSE score) in older adults with isolated systolic hypertension (p<0.001 for both).
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