Key result
Cardiac autonomic neuropathy in T2D is linked to ~15-fold greater odds of peripheral neuropathy.
Why the study?
The relationship between cardiac autonomic neuropathy and other micro- and macrovascular complications and risk factors in type 2 diabetes was investigated.
Cross-Sectional (n=149)
Odds Ratio: 15.47 (95% CI 5.16–46.38)
Cardiac autonomic neuropathy is highly prevalent (38.9%) in patients with type 2 diabetes and is strongly associated with modifiable risk factors and other vascular complications.
May support CAN screening in type 2 diabetes; leaves open independent links to micro/macrovascular complications.
UNLABELLED: The aim of this study was to investigate the relationship between cardiac autonomic neuropathy (CAN) and other micro- and macrovascular complications and risk factors for type 2 diabetes. We included, in this study, 149 patients with type 2 diabetes. We evaluated their cardiovascular risk factors, demographic data, and any major micro- and macrovascular complications of their diabetes. Assessments of CAN were based upon Ewing's battery. RESULTS: CAN was present in 38.9% of patients. In the CAN group, the duration of diabetes, BMI, systolic blood pressure, lipid levels, and HBA1c were all significantly higher than those in the other group. A significant association was found between CAN and retinopathy, peripheral neuropathy, ABI, and IMT. Multivariate logistic regression demonstrated that, in type 2 diabetes, the odds of CAN (OR (95% confidence intervals)) increase with the age of the patients (1.68 (1,4129-2.0025)), the average diabetes duration (0.57 (0.47-0.67)), cholesterol (1.009 (1.00-1.01)), HbA1c levels (1.88 (1.31-2.72)), peripheral neuropathy (15.47 (5.16-46.38)), BMI (1.12 (1.05-1.21)), and smoking (2.21 (1.08-4.53)). CONCLUSIONS: This study shows that CAN in type 2 diabetes is significantly associated with other macro- and microvascular complications and that there are important modifiable risk factors for its development.
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Moțățăianu et al. (2013) conducted a cross-sectional in Type 2 diabetes mellitus (n=149). Risk factors (e.g., peripheral neuropathy, HbA1c, smoking) vs. Absence of risk factors or lower levels was evaluated on Cardiac autonomic neuropathy (CAN) (OR 15.47, 95% CI 5.16-46.38). Cardiac autonomic neuropathy was present in 38.9% of patients with type 2 diabetes and was significantly associated with peripheral neuropathy (OR 15.47; 95% CI 5.16-46.38), smoking, and HbA1c.
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