March 27, 2015Psychology and Health
Depression and marital status determine the 10-year (2004–2014) prognosis in patients with acute coronary syndrome: The GREECS study
Key result
High depressive symptoms are linked to ~41% higher ACS incidence, while marriage predicts lower mortality.
- 41% higher risk
- 95% CI 14%-75%
- n=2,172
Why the study?
The association of depression and marital status with the long-term prognosis of acute coronary syndrome was not well examined in a Greek cardiac patient sample.
Do depression and marital status affect the 10-year prognosis in patients with acute coronary syndrome?
Population
2172 consecutive ACS patients from 6 hospitals in Greece
Comparison
Depression levels by CES-D score tertiles and marital status categories
Design
Prospective cohort study
Follow-up
10 years
Authors
Discussion
Loading...
Member takes
Implication
Depression and unmarried status linked to worse 10-year ACS prognosis; leaves open whether targeted support improves outcomes.
Study Design
Type
Cohort (n=2,172)
Multicenter
Yes
Structured PICO
Do depression and marital status affect the 10-year prognosis in patients with acute coronary syndrome?
P
Population
2,172 consecutive patients with acute coronary syndrome from 6 hospitals in Greece, followed for 10 years.
E
Exposure
Depression (evaluated using CES-D score) and marital status (single, married/cohabitants, divorced, widowed)
C
Comparator
Lowest tertile of CES-D score (<7) and single, widowed, or divorced marital status
O
Outcome
10-year ACS incidence and mortality (fatal and non-fatal cardiac events)hard clinical
Main Result
Effect estimate: 41% higher risk (95% CI 14%-75%)
Depression and being unmarried are associated with a significantly higher risk of recurrent ACS and mortality over 10 years in patients with acute coronary syndrome.
Cite This Study
Notara et al. (2015) conducted a cohort in Acute coronary syndrome (ACS) (n=2,172). Depression (CES-D score) and marital status vs. Lowest tertile of CES-D score (<7); single, widowed, or divorced was evaluated on ACS incidence (41% higher risk, 95% CI 14%-75%). High depressive symptoms were associated with a 41% higher risk of ACS incidence, while being married was associated with a 29% lower risk of ACS mortality over 10 years.