Key result
Lower oxygen delivery and longer intubation are linked to sternal wound infections after neonatal CHD surgery.
Why the study?
The incidence and perioperative risk factors for sternal wound infection in neonates after surgery for congenital heart disease were not well defined.
What are the perioperative risk factors for sternal wound infection in neonates after surgery for congenital heart disease?
Case-Control (n=253)
What are the perioperative risk factors for sternal wound infection in neonates after surgery for congenital heart disease?
Odds Ratio: 0.956 (95% CI 0.933–0.98)
p-value: p=<0.001
Postoperative oxygen delivery, duration of intubation, and surgical manipulation features are significant risk factors for sternal wound infection in neonates undergoing cardiac surgery.
May inform perioperative optimization of oxygen delivery and intubation in neonatal CHD surgery; leaves open causal confirmation in prospective studies.
Objectives: This study was undertaken to determine the incidence and risk factors associated with the development of sternal wound infection in neonates after surgery for congenital heart disease. Methods: A case–control study was conducted to examine the influence of perioperative risk factors on the development of sternal infection. In total, 253 neonates with CHD underwent a complete median sternotomy. To identify the risk factors influencing the development of sternal infection, multivariable logistic regression analysis was used. Results: Overall, 15 (5.9%) patients developed sternal wound infection after surgery. Deep wound infection occurred in six (2.4%) cases. As a result, the perioperative risk factors were the level of oxygen delivery in the postoperative period (OR: 0.956; CI: 0.933–0.98; p < 0.001), duration of intubation after surgery (OR: 1.04; CI: 1.003–1.079; p = 0.034) and application of surgical manipulation features (OR: 0.0004; CI: 0.000007–0.027; p < 0.001). Conclusions: The incidence of sternal infection in newborns can be reduced by simple and affordable methods. This will decrease the cost of patient care, length of hospitalization and the risk of secondary complications.
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Суворов et al. (2024) conducted a case-control in Congenital heart disease (n=253). Perioperative risk factors (postoperative oxygen delivery, intubation duration) was evaluated on Sternal wound infection (OR 0.956, 95% CI 0.933-0.98, p=<0.001). Postoperative oxygen delivery (OR 0.956; 95% CI 0.933-0.98) and intubation duration (OR 1.04) were significant perioperative risk factors for sternal wound infection in neonates after CHD surgery.
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