The Passerini reactions of indane-1,2,3-trione, tosylmethyl isocyanide, and benzoic acid derivatives proceed at room temperature giving sterically congested 2,2-disubstituted indane-1,3dione derivatives in quantitative yield.The reactions are one-pot, and the products obtained did not require any purification.
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Kazemizadeh et al. (2008) studied this question.
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