Key result
Laboratory-confirmed influenza linked to ~9-fold higher risk of AMI hospitalization.
Why the study?
Previous studies established an association between laboratory-confirmed influenza infection and hospitalization for acute myocardial infarction but did not establish causality or explore underlying mechanisms.
Does laboratory-confirmed influenza infection increase the risk of hospitalization for acute myocardial infarction in senior Veterans?
Population
391 hospitalizations for AMI among United States senior Veterans with laboratory-confirmed influenza infection
Comparison
Risk interval (first 7 days after influenza specimen collection) vs control interval (1 year before and after risk interval)
Design
Self-controlled case-series observational study with mediation analysis
Follow-up
+/- 1 year around positive influenza test
Authors
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Identifies candidate mediators of LCI-AMI link; hypothesis-generating and should not yet change practice.
Observational (n=391)
Does laboratory-confirmed influenza infection increase the risk of hospitalization for acute myocardial infarction in senior Veterans?
Relative Risk: 8.89 (95% CI 6.16–12.84)
Absolute Event Rate: 31.1% vs 3.5%
Laboratory-confirmed influenza infection is associated with a nearly 9-fold increased risk of acute myocardial infarction hospitalization in the first 7 days, with even higher risk observed in patients with elevated white blood cell or platelet counts.
Young‐Xu et al. (2020) conducted an observational in Acute myocardial infarction (n=391). Laboratory-confirmed influenza infection vs. Control interval (1 year before and 1 year after the risk interval) was evaluated on Hospitalization for acute myocardial infarction (IR 8.89, 95% CI 6.16-12.84). Laboratory-confirmed influenza infection was associated with a significantly increased risk of hospitalization for acute myocardial infarction (IR 8.89; 95% CI 6.16-12.84).
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