Key result
Childhood obesity links to early cardiovascular and renal alterations including LVH and progressive CKD.
Why the study?
Obesity in childhood is associated with early cardiovascular and renal alterations that increase the risk of chronic kidney disease and adverse health outcomes later in life.
Highlights the early onset of cardiovascular and renal alterations in obese children and emphasizes the importance of early lifestyle and pharmacological interventions.
May prompt earlier CV monitoring in obese children; leaves open whether interventions modify progression to CKD or LVH.
Childhood overweight and obesity is a relevant health condition with multi-organ involvement. Obesity shows significant tracking into adult life and is associated with an increased risk of serious adverse health outcomes both during childhood and later adulthood. The classical sequelae of obesity such as hypertension, metabolic syndrome and inflammation do develop at a paediatric age. Cardiovascular consequences, such as increased carotid intima-media thickness, and left ventricular hypertrophy, as well as functional alterations of the heart and arteries, are commonly traceable at an early age. Renal involvement can occur at a young age and is associated with a high probability of progressive chronic kidney disease. There is solid evidence suggesting that consequent treatment including both lifestyle changes and pharmacological therapy can reduce cardiovascular, metabolic and renal risks in obese children and adolescents.
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Doyon et al. (2013) conducted a review in Childhood overweight and obesity. Childhood overweight and obesity was evaluated. Childhood obesity is associated with early cardiovascular and renal alterations, including increased carotid intima-media thickness, left ventricular hypertrophy, and progressive chronic kidney disease.
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