Key result
Childhood obesity is linked to ~73% lower high molecular-weight adiponectin inversely correlated with visceral fat.
Why the study?
Japanese children are prone to obesity-induced metabolic derangement linked to serum adipocytokine profiles, but the specific relation of high molecular-weight adiponectin to metabolic abnormalities was unclear.
Does high molecular-weight adiponectin better reflect metabolic abnormalities than total adiponectin in obese children?
Comparison
High molecular-weight adiponectin vs total adiponectin levels
Design
Case-control study at a university hospital pediatric clinic
Authors
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H-Adn may mark metabolic derangement more specifically than T-Adn in obese Japanese children; leaves open whether it improves pediatric risk stratification.
Case-Control (n=87)
No
Does high molecular-weight adiponectin better reflect metabolic abnormalities than total adiponectin in obese children?
Absolute Event Rate: 1.3% vs 4.8%
High molecular-weight adiponectin is a better biomarker than total adiponectin for reflecting metabolic abnormalities and visceral fat accumulation in childhood obesity.
Araki et al. (2006) conducted a case-control in Childhood Obesity (n=87). Obesity vs. Nonobese children was evaluated on High molecular-weight adiponectin (H-Adn) levels. Obese children had significantly lower high molecular-weight adiponectin levels than nonobese controls (1.3 vs. 4.8 microg/ml), which inversely correlated with visceral fat area.
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