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Although silicon is a constituent of normal animal tissues, silicic acid formed by the dissolution of inhaled quartz particles can induce the formation of pathological lesions in which the normal tissue is replaced by fibrotic tissue arranged concentrically around the silica particles.The mechanism of the change which constitutes the disease, silicosis, is unknown.Schulman & Rideal (1937) demonstratedthe interaction of a protein with silicic acid by injecting the acid beneath a monolayer of gliadin at pH 6.2.The silicic acid was adsorbed to the protein layer and after 12 hr.produced a film which could not be penetrated or dispersed by sodium oleate.This communication describes a more extensive study designed to investigate the conditions under which proteins react with silicic acid and to deter- mine which of their functional groups are responsible for the interaction.Two methods of study were
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Holt et al. (1954) studied this question.
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