Breast size and cancer.

nauseated and vomited.In addition to these well-known local irritant effects of zinc sulphate on the gastrointestinal tract, con- sideration must be given to potentially toxic side effects of the large and unphysiological concentrations of zinc achieved in human plasma with the recommended zinc sulphate regimen.In the light of these observations we feel that the current recommendations to treat acne vulgaris with 220 mg of zinc sulphate thrice daily is unwarranted owing to the excess quantity of zinc ion absorbed.There is an urgent need to investigate the dose effectiveness of zinc sulphate supplementation not only in patients with acne vulgaris but also in the various other conditions for which zinc has been recommended.This is being done in this department.