Key result
Spironolactone linked to greater BP reduction in essential hypertension with hyporesponsive versus normal renin activity.
Why the study?
The hypotensive effect of spironolactone in various forms of hypertension, including essential, renal, and mineralocorticoid hypertension, was studied to understand variable blood pressure responses.
Does spironolactone reduce blood pressure in patients with various forms of hypertension?
Observational (n=24)
Does spironolactone reduce blood pressure in patients with various forms of hypertension?
The blood pressure response to spironolactone varies significantly based on the underlying etiology of hypertension and baseline renin activity.
Should not yet guide spironolactone use by renin status; hypothesis-generating case observation requiring prospective validation.
The hypotensive effect of spironolactone has been studied in twenty-four patients with various forms of hypertension. 2. In essential hypertension a greater fall of blood pressure was achieved in patients with renin activity hyporesponsive to postural change than in those in whom renin responded normally to posture. 3. A poor hypotensive response was observed in patients with renal or renal arterial disease and secondary aldosteronism. 4. The variable hypotensive response seen in patients with primary aldosteronism predicted the response to adrenal surgery. 5. Blood pressure was not lowered by spironolactone in one case of 17-hydroxylation deficiency or in one case of malignant ovarian arrhenoblastoma producing aldosterone.
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Mantero et al. (1973) conducted an observational in Hypertension (essential, renal, and mineralocorticoid) (n=24). Spironolactone vs. Normal renin response to posture / other hypertension types was evaluated on Fall of blood pressure (hypotensive effect). Spironolactone produced a greater fall in blood pressure in essential hypertension patients with hyporesponsive renin activity compared to those with a normal renin response to posture.
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