Key result
Artemisinin derivatives show preclinical promise for metabolic syndrome by improving insulin sensitivity and reducing inflammation.
Artemisinin and its derivatives show preclinical promise as multi-target metabolic modulators for metabolic syndrome, though clinical translation requires further long-term safety and efficacy studies.
Preclinical metabolic benefits of artemisinin derivatives remain hypothesis-generating; clinical trials needed to assess human translation.
Metabolic syndrome (MetS) is a complex of disorders, characterized by insulin resistance accompanied by abdominal obesity, dyslipidemia, hypertension and impaired glucose metabolism.This group of conditions notably increases the risk of type 2 diabetes mellitus and cardiovascular or cerebrovascular diseases and has become a major global public health challenge.current treatments for MetS often fail to meet clinical needs owing to the limitations associated with single-target therapies and notable side effects.artemisinin-based drugs are primarily used as antimalarial drugs but have garnered widespread attention for their broad biological activities.Preclinical evidence suggests that artemisinin and its derivatives improve insulin sensitivity, regulate lipid metabolism, alleviate chronic inflammation and reshape the gut microbiota by modulating multiple metabolism-related signaling pathways, including aMP-activated protein kinase, Pi3K/akt, nF-κB and Toll-like receptor 4, indicating a potential therapeutic avenue for MetS.However, most of these findings are derived from cell-based and animal studies, while direct clinical evidence in patients with MetS remains limited. in the present review, the therapeutic potential and core molecular mechanisms of artemisinin and its derivatives for MetS are summarized and the challenges and opportunities for their future clinical translation are discussed.Contents 1. introduction 2. Structural basis and pharmacological effects of artemisinin and its derivatives 3. Mechanisms of artemisinin and its derivatives in regulating MetS 4. clinical applications and emerging therapeutic strategies for artemisinin and its derivatives 5. conclusion and outlook
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Cao et al. (2026) conducted a review in Metabolic syndrome. Artemisinin and its derivatives was evaluated. Artemisinin and its derivatives demonstrate therapeutic potential for metabolic syndrome in preclinical models by improving insulin sensitivity, regulating lipid metabolism, and alleviating chronic inflammation, though direct clinical evidence remains limited.
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