Key result
Insulin resistance in rural PCOS adolescents is linked to ~65% higher triglycerides and lower HDL.
Why the study?
The incidence and diagnostic criteria of PCOS in adolescence are not well defined, and its symptoms overlap with normal pubertal changes, complicating diagnosis.
Cross-Sectional (n=85)
No
Absolute Event Rate: 115.2% vs 70%
p-value: p=<0.001
Hospital-based PCOS prevalence of 9.4% warrants targeted screening in symptomatic women; leaves open true community burden and causal links.
BACKGROUNDPolycystic ovarian syndrome (PCOS) is the most complex and common endocrinological disorder involving 5-11% of women in their reproductive age.This prevalence ranges from 2.2% to 26% in adult women in 18-45 years age group.In a recent study, the prevalence of a confirmed diagnosis of PCOS in adolescents aged 10 to 19 years was 5-15%, which increased to 10-22% when undiagnosed cases with documented symptoms qualifying for PCOS according to NIH (National institute of Health) criteria were included.PCOS is a complex endocrine disorder which is most common in women of reproductive age.PCOS may first present in adolescence, but the incidence of PCOS in adolescence is not known, as diagnostic criteria for PCOS in their adolescent age is still not defined.PCOS symptoms tend to overlap with normal pubertal changes making the diagnosis even more challenging.The objective is to study prevalence and symptomatology of polycystic ovary syndrome (PCOS) in adolescent girls.In adolescents with PCOS, dyslipidaemia, diabetes as well as obesity are all potent cardiovascular risk factors in their future reproductive life.It is a metabolic disorder which may not be related with obesity only, in lean PCOS also we can see its manifestations.
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Laddad et al. (2019) conducted a cross-sectional in Polycystic Ovarian Syndrome (PCOS) (n=85). Insulin resistance vs. Insulin sensitivity was evaluated on Triglycerides (mg/dl) (p=<0.001). In rural adolescents with PCOS, insulin resistance was significantly associated with higher triglycerides (115.2 vs 70 mg/dl) and lower HDL cholesterol (37 vs 52 mg/dl), independent of obesity markers.
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