Key result
Elevated urinary LRG1, ORM1, and ORM2 distinguish adult-onset Still's disease from controls with ORM1 AUC ~0.84.
Why the study?
A rapid, efficient, and noninvasive diagnostic method is urgently needed to improve therapy for adult-onset Still's disease (AOSD).
Do urinary levels of LRG1, ORM1, and ORM2 serve as diagnostic biomarkers for Adult-onset Still's disease?
Case-Control (n=185)
No
Do urinary levels of LRG1, ORM1, and ORM2 serve as diagnostic biomarkers for Adult-onset Still's disease?
Effect estimate: AUC 0.837
p-value: p=<0.001
Urinary LRG1, ORM1, and ORM2 are elevated in Adult-onset Still's disease and may serve as novel noninvasive biomarkers for its diagnosis.
No takes yet. Share an insight, caveat, or question.
May aid noninvasive AOSD diagnosis; hypothesis-generating and requires prospective validation before clinical adoption.
Sun et al. (2020) conducted a case-control in Adult-onset Still's disease (AOSD) (n=185). Elevated urinary LRG1, ORM1, and ORM2 vs. Healthy controls and disease controls was evaluated on Diagnostic accuracy (Area Under the Curve) for distinguishing AOSD from non-AOSD subjects (AUC 0.837, p=<0.001). Elevated urinary levels of LRG1, ORM1, and ORM2 accurately distinguished patients with adult-onset Still's disease from healthy and disease controls, with ORM1 demonstrating an AUC of 0.837.
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