Key result
Time-resolved fluorescence chromatography detects GII human norovirus with ~97% overall accuracy.
Why the study?
A rapid, sensitive, and wide detection range method for GII human norovirus is needed to aid early clinical diagnosis and population screening.
Does time-resolved fluorescence chromatography accurately detect GII human norovirus in clinical samples?
Cross-Sectional (n=88)
Does time-resolved fluorescence chromatography accurately detect GII human norovirus in clinical samples?
Effect estimate: AUC 0.9670 (95% CI 0.9289-1.000)
A time-resolved fluorescence chromatography method provides a rapid and sensitive diagnostic tool for GII human norovirus detection.
May aid GII norovirus detection in research labs; leaves open routine clinical adoption pending larger validation.
. There was no cross reaction with rotavirus type A and enteric adenovirus type 40 lysate. In 88 clinical samples, the positive coincidence rate was 97.06%, the negative coincidence rate was 96.27%, and the total coincidence rate was 96.60%. The area under the subject operating characteristic curve was 0.9670 and the 95% confidence interval was (0.9289,1.000). Therefore, this study established a rapid, sensitive and wide detection range of GII human norovirus detection method, which can provide an auxiliary diagnostic method for early clinical diagnosis of norovirus and population screening.
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Wang et al. (2025) conducted a cross-sectional in GII human norovirus (n=88). Time-resolved fluorescence chromatography was evaluated on Diagnostic accuracy (AUC and coincidence rates) (AUC 0.9670, 95% CI 0.9289-1.000). Time-resolved fluorescence chromatography for GII human norovirus detection showed a total coincidence rate of 96.60% and an AUC of 0.9670 (95% CI 0.9289-1.000) in 88 clinical samples.
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