Key result
Comorbidities in pediatric peritoneal dialysis are linked to ~17% lower 4-year survival and more hospitalizations.
Why the study?
Hospitalization and mortality rates in pediatric dialysis patients remain high, and large-scale data describing comorbidities and their impact on outcomes beyond the newborn period were lacking.
Does the presence of comorbidities increase hospitalization rates and mortality in pediatric chronic peritoneal dialysis patients?
Population
1830 pediatric chronic peritoneal dialysis patients aged 0-19 years from the International Pediatric Peritoneal Dialysis Network registry
Comparison
Presence of at least 1 comorbidity vs absence of comorbidities
Design
International registry-based cohort study
Follow-up
Median 15.2 months (range 0.2-80.9 months)
Authors
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Comorbidities identify high-risk pediatric PD patients; leaves open whether targeted management improves survival.
Cohort (n=1,830)
Yes
Does the presence of comorbidities increase hospitalization rates and mortality in pediatric chronic peritoneal dialysis patients?
Absolute Event Rate: 73% vs 90%
p-value: p=<0.0001
In pediatric chronic peritoneal dialysis patients, the presence of comorbidities is common and significantly associated with increased hospitalization rates and decreased survival.
Neu et al. (2012) conducted a cohort in Pediatric chronic peritoneal dialysis (n=1,830). Presence of at least 1 comorbidity vs. No comorbidity was evaluated on 4-year survival rate (p=<0.0001). The presence of at least one comorbidity in pediatric chronic peritoneal dialysis patients was associated with decreased 4-year survival (73% vs 90%, p<0.0001) and higher hospitalization rates.
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