Tumor-Intrinsic Blood and Imaging Correlatives in Advanced Prostate Cancer Treated with Combination Radiopharmaceutical Therapy and Immunotherapy

Sofie H. Tolmeijer; Edmond M. Kwan; Andrei Gafita; Anis A. Hamid; Shivakumar Keerthikumar; Narjess Ayati; Mathias Bressel; Anthony M. Joshua; Louise Emmett; Megan Crumbaker; Sarah W.S. Ng; Gráinne Donnellan; A. Antón; Lavinia Spain; Lisa G. Horvath; Joanna Chan; James P. Buteau; Arielle van Mourik; Nattakorn Dhiantravan; Andrisha-Jade Inderjeeth; Martin Sjöström; Aishwarya Subramanian; Santosh Gupta; Narelle Williams; Anupama Pasam; D. Olmos; Nicole M. Haynes; Paul J. Neeson; David Quigley; David L. Goode; Rodney J. Hicks; Michael S. Hofman; Alexander W. Wyatt; Shahneen Sandhu

doi:10.2967/jnumed.126.273266

Key Points

To identify molecular and imaging determinants of response and resistance to combination radiopharmaceutical therapy and immunotherapy in advanced prostate cancer.
Evaluated patients with advanced prostate cancer receiving combination radiopharmaceutical therapy and immunotherapy.
Conducted integrated analyses of tumor-intrinsic blood correlatives and imaging features to assess therapeutic determinants.
Identified distinct integrated molecular and imaging features that correlate with therapeutic response versus treatment resistance.
Defined biomarker strategies to inform patient stratification and optimize future clinical trial development for combination regimens.

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Implication

Translational study uncovers molecular and imaging determinants of therapy response in advanced prostate cancer, suggesting biomarker strategies to guide combination treatments.

Abstract

We provide the first integrated molecular and imaging insights into determinants of response and resistance to combined radiopharmaceutical therapy and immunotherapy in prostate cancer and propose biomarker strategies to inform future clinical development.

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Cite This Study

Tolmeijer et al. (2026) studied this question.

synapsesocial.com/papers/6aae4f437491ebcd77741e93 https://doi.org/10.2967/jnumed.126.273266

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Tumor-Intrinsic Blood and Imaging Correlatives in Advanced Prostate Cancer Treated with Combination Radiopharmaceutical Therapy and Immunotherapy

Key Points

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Implication

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Discussion

Cite This Study

Tumor-Intrinsic Blood and Imaging Correlatives in Advanced Prostate Cancer Treated with Combination Radiopharmaceutical Therapy and Immunotherapy

Key Points

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Implication

Abstract

Discussion

Cite This Study

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