Key result
Diabetes linked to ~23% lower 6-year survival in CAD patients with silent ischemia.
Why the study?
The clinical significance of ischemic ST depression without anginal chest pain during exercise testing in patients with diabetes mellitus and documented CAD was unclear.
Does silent myocardial ischemia during exercise testing predict worse survival in patients with diabetes mellitus compared to nondiabetic patients or diabetic patients without ischemia?
Comparison
Diabetic patients with silent ischemia vs symptomatic ischemia vs no ischemia and nondiabetic patients with silent ischemia
Design
Cohort study from the Coronary Artery Surgery Study registry
Follow-up
6 years
Authors
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Silent ischemia on exercise testing signals higher mortality in diabetic CAD patients; leaves open revascularization benefit in 3-vessel disease.
Cohort (n=542)
Does silent myocardial ischemia during exercise testing predict worse survival in patients with diabetes mellitus compared to nondiabetic patients or diabetic patients without ischemia?
Absolute Event Rate: 59% vs 82%
p-value: p=<0.001
Silent myocardial ischemia during exercise testing in diabetic patients with coronary artery disease is associated with significantly worse 6-year survival compared to nondiabetic patients or diabetic patients without ischemia.
Weiner et al. (1991) conducted a cohort in Diabetes mellitus and coronary artery disease (n=542). Diabetes mellitus with silent myocardial ischemia vs. Nondiabetic patients with silent myocardial ischemia was evaluated on 6-year survival (p=<0.001). Among patients with CAD and silent ischemia during exercise testing, 6-year survival was significantly worse in those with diabetes compared to those without diabetes (59% vs 82%, p<0.001).
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