Key result
Higher cumulative metabolic syndrome severity score linked to ~45% greater risk of arterial stiffness.
Why the study?
The relationship between metabolic syndrome severity score and arterial stiffness was not well established in a large cohort study.
Is a higher cumulative metabolic syndrome severity z score associated with an increased risk of arterial stiffness in a Chinese cohort?
Cohort (n=7,621)
Is a higher cumulative metabolic syndrome severity z score associated with an increased risk of arterial stiffness in a Chinese cohort?
Hazard Ratio: 1.45 (95% CI 1.24–1.69)
A higher cumulative metabolic syndrome severity score is associated with an increased risk of arterial stiffness, particularly in younger, non-obese, non-hypertensive, and non-diabetic individuals.
May inform risk stratification by cumulative severity; hypothesis-generating for arterial stiffness prevention in observational data.
BACKGROUND AND AIMS: To investigate the relationship between metabolic syndrome severity z score(MetS-Z) and arterial stiffness(AS). METHODS AND RESULTS: A total of 7621 participants who took three physical examination and brachial-ankle pulse wave velocity(ba-pwv) test from 2006 were enrolled. Cumulative MetS-Z(cMetS-Z) was calculated by using blood pressure, triglycerides, HDL cholesterol, blood glucose and BMI. AS was assessed by ba-pwv. Cox regression model was used to evaluate the risk of AS. All participants were divided into four groups according to cMetS-Z(Q1-Q4). The average age of the participants was 43.06 ± 8.91 years old. During a median follow-up of 6.27 years, 1831cases of AS were identified. The incident rate of AS increased gradually from group Q1 to Q4. Compared with the lowest cMetS-Z(group Q1), the adjusted hazard ratio (HR) and 95% confidence interval (CI) of group Q2-Q4 for AS were 1.27 (1.09-1.47),1.28(1.10-1.48) and 1.45 (1.24-1.69) respectively. The cubic spline model indicated cMetS-Z had a liner relationship with AS and the cut-off value was lower than zero. Sub-group analysis suggested cMetS-Z was related to AS especially among participants who were younger and without obesity or hypertension or diabetes. CONCLUSION: Higher cMetS-Z was associated with an increased risk of AS in this cohort community study, and this relationship seemed to be stronger among normal healthy subjects. REGISTRATION NUMBER: ChiCTR-TNC-11001489. CLINICAL TRIAL: January 1st 2006, ChiCTR-TNC-11001489 and 2011.
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Wang et al. (2024) conducted a cohort in Arterial stiffness (n=7,621). Cumulative metabolic syndrome severity z score (cMetS-Z) vs. Lowest cMetS-Z quartile (Q1) was evaluated on Arterial stiffness (HR 1.45, 95% CI 1.24-1.69). Higher cumulative metabolic syndrome severity z-score was associated with an increased risk of arterial stiffness (HR 1.45; 95% CI 1.24-1.69 for the highest vs lowest quartile).
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