Key result
FTO and MC4R SNPs are linked to higher obesity risk in Tatar women.
Why the study?
Genetic predisposition to obesity involving variants of FTO and MC4R genes has been widely discussed, but their association in Tatar women was not established.
Are polymorphic variants of FTO and MC4R genes associated with obesity in Tatar women?
Case-Control (n=670)
Are polymorphic variants of FTO and MC4R genes associated with obesity in Tatar women?
Genetic variability in FTO and MC4R genes is significantly associated with the development of obesity in Tatar women from Russia.
Answers are grounded in this paper and cite their sources.
Supports FTO/MC4R variant screening in Tatar women; leaves open generalizability and clinical utility.
Obesity is a chronic relapsing disease that leads to numerous ailments and requires lifelong treatment. Genetic predisposition is one of the mostly discussed aspects of obesity development, and genome-wide association studies have provided evidence that several variants of the FTO and MC4R genes are significantly associated with obesity. In this study the association of FTO (rs9939609, rs7202116, and rs9930506) and MC4R (rs12970134 and rs17782313) genes' SNPs with obesity in Tatar women has been analyzed. In the investigation 340 women with obesity (Body Mass Index (BMI) ≥ 30 kg/m2) and 330 women from a control group (BMI up to 24.9 kg/m2) took part. The FTO rs9939609 (p = 0.0002) and rs9930506 (p = 0.0005) SNPs were shown to be associated with obesity risk following an additive model, while the MC4R rs12970134 (p = 0.0076) and rs1778231 (p = 0.021) SNPs were associated by a recessive model. We also showed an association of quantitative parameters (age, weight, and BMI) with two the FTO rs9939609 and rs9930506 SNPs and the association of age and the MC4R rs12970134 SNP. Our study demonstrates the role of genetic variability in FTO and MC4R genes in obesity development in Tatar women from Russia.
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Кочетова et al. (2014) conducted a case-control in Obesity (n=670). FTO and MC4R gene SNPs vs. Control group (BMI up to 24.9 kg/m2) was evaluated on Obesity risk (p=0.0002). FTO (rs9939609, rs9930506) and MC4R (rs12970134, rs1778231) gene SNPs were associated with obesity risk in Tatar women.
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