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Tryptanthrin (indolo[2,1-b]quinazoline-6,12-dione) is a natural product which shows significant biological activity as an antibacterial, antiparasitic, and antineoplastic agent.Historically, tryptanthrin has been found as a component of many dyes as well as a constituent of medicinal herbal treatments.This review describes the synthesis of tryptanthrin and some related compounds which also have a quinazoline ring fused to an indolo moiety as a core.
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Tucker et al. (2012) studied this question.
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