Key result
E. coli-induced sepsis upregulates uK(ATP)-1 channel protein expression ~9-fold in rat diaphragms.
Why the study?
The effect of sepsis on the expression of the ubiquitously expressed ATP-sensitive potassium (uK(ATP)-1) channel was not well characterized.
Population
Sprague-Dawley rat diaphragms
Comparison
20 mg/Kg E. coli lipopolysaccharides vs 0.5 ml saline
Design
Preclinical experimental study
Follow-up
3 to 48 hours
Authors
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No immediate change to sepsis care; leaves open whether uK(ATP)-1 upregulation contributes to diaphragmatic dysfunction in humans.
Effect estimate: 9-fold increase
Sepsis induced by endotoxemia significantly upregulates the expression of the uK(ATP)-1 channel in rat diaphragms.
Czaika et al. (2000) studied Sepsis / endotoxemia. E. coli lipopolysaccharides vs. 0.5 ml saline was evaluated on uK(ATP)-1 channel expression (9-fold increase). Sepsis induced by E. coli lipopolysaccharides upregulated uK(ATP)-1 channel protein expression by approximately 9-fold at 24 hours in rat diaphragms.
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