A technique for the simultaneous measurement of three vascular parameters: blood flow (Fρ), blood volume (vb), and the capillary permeability-surface area product (PSρ) in breast tumors using dynamic contrast-enhanced magnetic resonance imaging (MRI) is presented. Features of the technique include measurement of precontrast tumor T1, rapid temporal sampling, measurement of the arterial input function, and use of a distributed parameter tracer kinetic model. Parameter measurements are compared that were determined using two contrast agents of different molecular weights, gadolinium-diethylene triamine pentaacetic acid (Gd-DTPA; 0.6 kDa) and Gadomer-17 (17 kDa), in 18 spontaneous canine mammary tumors. Measurements of Fρ and vb corresponded well with literature values, and the mean PSρ measured using Gd-DTPA was a factor of 15 higher than that measured using Gadomer-17. J. Magn. Reson. Imaging 2000;12:991–1003.
No takes yet. Share an insight, caveat, or question.
Henderson et al. (2000) studied this question.