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August 12, 2014Angiology

Reduced Protein C Activity Might be Associated With Progression of Peripheral Arterial Disease

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Key result

Lower protein C activity and female sex are linked to CLI in PAD patients.

  • n=150

Why the study?

The effect of reduced protein C and protein S activities on the progression of peripheral arterial disease was evaluated due to their potential role in disease severity.

Population

106 patients with PAD and 44 patients with AAA

Comparison

Patients with critical limb ischemia vs patients with intermittent claudication

Design

Observational study measuring protein C and protein S activities

Authors

HKHiroyoshi KomaiKansai Medical UniversitySSShunya ShindoUniversity of Yamanashi HospitalMSMasahiro SatoAsahikawa Medical University

Discussion

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Implication

May refine CLI risk stratification in PAD; leaves open causality and need for prospective validation.

Study Design

Type

Observational (n=150)

Structured PICO

P
Population
150 patients, including 106 with peripheral arterial disease and 44 with abdominal aortic aneurysm, evaluated for protein C and S activities.
O
Outcome
Progression of peripheral arterial disease to critical limb ischemia (CLI)hard clinical

Reduced protein C activity may serve as an independent predictor for the progression of peripheral arterial disease to critical limb ischemia.

Cite This Study

Komai et al. (2014) conducted an observational in Peripheral arterial disease and abdominal aortic aneurysm (n=150). Reduced protein C and protein S activities vs. Normal protein C and S activities was evaluated on Critical limb ischemia (CLI). Lower protein C activity and female gender were independent determinant factors for critical limb ischemia in patients with peripheral arterial disease.

synapsesocial.com/papers/6aaf2c874eda70efabf16697https://doi.org/10.1177/0003319714544946
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Frequency of natural coagulation inhibitor (antithrombin III, protein C and protein S) deficiencies in Japanese patients with spontaneous deep vein thrombosis2001 · 59 citations
  2. 2Residual thrombin generation potential is inversely linked to the occurrence of atherothrombotic events in patients with peripheral arterial disease2014 · 22 citations
  3. 3The prevalence of thrombophilia in patients with symptomatic peripheral vascular disease2006 · 19 citations
  4. 4Hypercoagulability Markers in Patients with Peripheral Arterial Disease: Association to Ankle-brachial Index2008 · 16 citations
  5. 5Incidence, Natural History and Cardiovascular Events in Symptomatic and Asymptomatic Peripheral Arterial Disease in the General Population1996 · 667 citations