January 2, 2014European Journal of Clinical Investigation

Residual thrombin generation potential is inversely linked to the occurrence of atherothrombotic events in patients with peripheral arterial disease

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Why the study?

Does low thrombin generation potential predict atherothrombotic events in patients with PAD undergoing infrainguinal angioplasty and stenting?

Population

108 patients undergoing infrainguinal angioplasty and stenting for lower extremity artery disease classified…

Design

Cohort

Follow-up

2-year

Authors

TGThomas GremmelInterventional Cardiology RKRenate KoppensteinerVascular Medicine CACihan AyCardio-Oncology

Discussion

Member takes

Implication

Does not support routine thrombin generation testing in PAD stenting; hypothesis-generating for its role in atherothrombotic risk prediction.

Structured PICO

Does low thrombin generation potential predict atherothrombotic events in patients with PAD undergoing infrainguinal angioplasty and stenting?

Population

108 patients (104 analyzed) undergoing infrainguinal angioplasty and stenting for lower extremity artery disease classified as Rutherford stages of peripheral arterial disease (PAD) 2-3.

Intervention

Measurement of thrombin generation potential

Outcome

Composite atherothrombotic endpoint of myocardial infarction, ischaemic stroke or transient ischaemic attack, and cardiovascular death within 2-year follow-upcomposite

Low residual thrombin generation potential is inversely correlated with PAR-1-mediated platelet activation and predicts future atherothrombotic events in patients with PAD undergoing angioplasty and stenting.

Cite This Study

Gremmel et al. (2014) studied this question.

synapsesocial.com/papers/6a703abc2163a0a01bc473a5 https://doi.org/10.1111/eci.12236

Topics

Dual antiplatelet therapy Women and heart disease

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Implication

Does not support routine thrombin generation testing in PAD stenting; hypothesis-generating for its role in atherothrombotic risk prediction.

Residual thrombin generation potential is inversely linked to the occurrence of atherothrombotic events in patients with peripheral arterial disease

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Topics

Residual thrombin generation potential is inversely linked to the occurrence of atherothrombotic events in patients with peripheral arterial disease

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Topics

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