Why the study?
Is plasma thrombin generation associated with incident coronary heart disease and stroke in elderly patients with vascular disease or risk factors?
Is plasma thrombin generation associated with incident coronary heart disease and stroke in elderly patients with vascular disease or risk factors?
Delayed and decreased thrombin generation is a strong and independent predictor for incident stroke, but not consistently for coronary heart disease, in elderly patients at increased vascular risk.
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Decreased thrombin generation may identify higher stroke risk in elderly vascular patients; hypothesis-generating and should not yet change practice.
Loeffen et al. (2014) studied this question.
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