Key result
ADIPOQ rs17300539 polymorphism, unlike rs12495941, links to PCOS risk in a Chinese Han population.
Why the study?
Adiponectin plays an important role in insulin sensitivity and resistance in PCOS, but the association of ADIPOQ gene polymorphisms with PCOS in a Chinese population was unclear.
Do ADIPOQ gene polymorphisms rs12495941 and rs17300539 associate with the risk of polycystic ovary syndrome in a Chinese population?
Case-Control (n=783)
Do ADIPOQ gene polymorphisms rs12495941 and rs17300539 associate with the risk of polycystic ovary syndrome in a Chinese population?
The ADIPOQ rs17300539 polymorphism is strongly associated with the risk of PCOS in a Chinese Han population.
Should not yet inform PCOS risk assessment; extends ADIPOQ variant data in Chinese Han women but remains hypothesis-generating.
BACKGROUND Polycystic ovary syndrome (PCOS) is a complex disease that has both genetic and environmental components. Adiponectin plays an important role in the regulation of insulin sensitivity and insulin resistance (IR) in PCOS. The aim of this study was to determine 2 single-nucleotide polymorphisms (SNPs) variants (rs12495941 and rs17300539) of the adiponectin gene (ADIPOQ) in polycystic ovary syndrome (PCOS) families. MATERIAL AND METHODS We recruited 197 PCOS probands, their biological parents, and 192 controls. Anthropometric variables, including hip circumference (HC) and waist circumference (WC), were measured in all subjects during their first visit to the outpatient department. Serum T, FBG, FINS, TC, TG, LDL, and HDL levels were measured. PCOS patients were divided into 2 groups based on BMI: group A (BMI <25 kg/m²) and group B (BMI ≥25 kg/m²). Parents of PCOS were accordingly categorized into group C and group D (fathers), and group E and group F (mothers). The associations among ADIPOQ rs12495941, rs17300539, and PCOS were analyzed using the transmission disequilibrium test (TDT). RESULTS A significant association was found between SNP rs17300539 and PCOS in our Chinese population. The levels of TG and FINS and the genotype frequencies of rs17300539 are significantly different between overweight and lean PCOS. No significant association was detected for rs12495941. CONCLUSIONS TDT confirms that rs17300539 of ADIPOQ is strongly associated with the risk of PCOS in a Chinese Han population, but rs12495941 of ADIPOQ is not associated with the occurrence of PCOS.
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Sun et al. (2017) conducted a case-control in Polycystic ovary syndrome (PCOS) (n=783). ADIPOQ rs17300539 and rs12495941 polymorphisms vs. Controls without the polymorphisms was evaluated on Association with PCOS risk. The ADIPOQ rs17300539 polymorphism was significantly associated with PCOS risk in a Chinese Han population, whereas rs12495941 showed no significant association.
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