Key result
Adiponectin TGTG haplotype is linked to a ~22% higher absolute frequency in women with PCOS.
Why the study?
Are adiponectin gene SNPs 45T/G and 276G/T and their haplotypes associated with PCOS and cardiovascular risk factors?
Case-Control (n=1,580)
Are adiponectin gene SNPs 45T/G and 276G/T and their haplotypes associated with PCOS and cardiovascular risk factors?
Absolute Event Rate: 41.3% vs 18.9%
p-value: p=0.001
The TGTG haplotype of the adiponectin gene is associated with increased susceptibility to PCOS and higher systolic blood pressure in affected women.
TGTG haplotype associated with PCOS susceptibility; hypothesis-generating for CV risk links, needs prospective confirmation before clinical consideration.
BACKGROUND: Haplotypes of adiponectin gene single nucleotide polymorphisms (SNP) might be related to metabolic disorders. AIM: To assess whether the prevalence of SNP 45T/G and 276G/T of the adiponectin gene and their haplotypes differ between polycystic ovary syndrome (PCOS) and non-hirsute cycling controls and to investigate the relationship between these haplotypes and risk factors for cardiovascular disease. SUBJECTS AND METHODS: In this case-control study, 80 women with PCOS and 1500 non-hirsute controls with regular cycles underwent clinical and laboratory measurements. Genotype distribution was analyzed by conventional PCR-restriction fragment length polymorphism. RESULTS: Compared to controls, PCOS women had greater body mass index (BMI) (31.0±7.9 kg/m² vs 23.4±4.6 kg/m²; p<0.001), waist circumference (92.2±18.8 cm vs 74.5±10.2 cm; p<0.001), and systolic and diastolic blood pressure (124.6±19.9 vs 111.5±13.0 mmHg and 79.2±12.5 vs 71.8±10.6 mmHg; p<0.025), as well as a worse lipid profile (p<0.007), even after adjustment for age and BMI. Genotype distribution was similar in PCOS and controls (45T/G: p=0.399; 276G/T: p=0.135). Six haplotypes were inferred and their frequencies differed significantly between the groups (p=0.001). The TGTG haplotype was more frequent in PCOS than controls (41.3 vs 18.9%). In PCOS, the GG genotype for SNP 276 (p=0.031) and the TGTG haplotype (p=0.023) were associated with higher systolic blood pressure vs other genotypes and haplotypes. Body composition, glucose, insulin, and lipid profile were similar across genotypes and haplotypes in both groups. CONCLUSIONS: Haplotype TGTG from adiponectin gene variants 45T/G and 276G/T is related to susceptibility to PCOS, and might be associated with increased blood pressure in PCOS.
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Radavelli‐Bagatini et al. (2014) conducted a case-control in Polycystic ovary syndrome (PCOS) (n=1,580). Polycystic ovary syndrome (PCOS) vs. Non-hirsute cycling controls was evaluated on Frequency of the TGTG haplotype (p=0.001). The TGTG haplotype of the adiponectin gene was significantly more frequent in women with polycystic ovary syndrome than in controls (41.3% vs 18.9%, p=0.001).
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