Key result
Review details perindopril and amlodipine effects on endothelial function in COVID-19 with HTN or CHD.
Why the study?
Endothelial dysfunction is a key pathophysiological process in severe and prolonged COVID-19, especially in patients with hypertension and/or coronary heart disease, but the effects of perindopril and amlodipine on endothelial function in this context require clarification.
Does a perindopril and amlodipine combination improve endothelial function in patients with hypertension and/or coronary artery disease and COVID-19?
Does a perindopril and amlodipine combination improve endothelial function in patients with hypertension and/or coronary artery disease and COVID-19?
This review highlights the potential of perindopril and amlodipine to improve endothelial dysfunction, a key pathophysiological process in severe COVID-19, among patients with hypertension or coronary artery disease.
Should not yet change practice in COVID-19 patients with hypertension or CAD; leaves open the endothelial effects of perindopril-amlodipine pending prospective trials.
The outbreak of the coronavirus disease 2019 (COVID-19) pandemic is an ongoing public health emergency that has caused unprecedented morbidity and mortality. COVID-19 is a disease caused by severe acute respiratory syndromerelated coronavirus 2 (SARS-CoV-2), which affects not only the lungs but also the cardiovascular system. A strong theoretical justification for the multisystem effect of COVID-19 is the close relationship between it and endothelial dysfunction, which, according to expert consensus, is crucial for the pathogenesis and severity of the disease. Endothelial dysfunction is considered as the main pathophysiological process in the severe and/or prolonged course of COVID-19, and is probably the common denominator of many clinical aspects of severe COVID-19. This review presents scientific data on the effect of perindopril and amlodipine in patients with hypertension and/or coronary heart disease and COVID-19 on endothelial function.
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Polyakova et al. (2022) conducted a review in Hypertension and/or coronary artery disease and COVID-19. Perindopril and amlodipine was evaluated on Endothelial function. This review presents scientific data on the effect of perindopril and amlodipine on endothelial function in patients with hypertension and/or coronary heart disease and COVID-19.
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